Assisted Reproduction

At our clinic, Assisted Reproduction is tailored to every couple’s needs according to both the patient’s health condition and personal requests.

Hereinafter, you can familiarize yourself with a typical progression of the entire treatment, starting with the preparatory phase, all the way to the transfer of a healthy embryo to a mother’s uterus.

  • 1Preparatory phase

    Preparatory
    phase

    During the preliminary phase, a diagnosis of infertility is carried out on the couple, a suitable procedure is defined, the ovaries are stimulated, sperm cells and oocytes are retrieved, and a decision to proceed with donor eggs/sperm is made, as the case may be.
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  • 2Egg fertilization

    Egg
    fertilization

    Egg fertilization will be performed via one of three methods based on health considerations and the wishes of the couple.
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  • 3Prolonged cultivation

    Prolonged
    cultivation

    After fertilization of the egg, a prolonged embryo cultivation is carried out. It provides a greater chance for the blastocyst to attach itself to the uterus while allowing for the opportunity to select the best and healthiest egg. We monitor and analyse the progress of their development during the first five days. During this 5-day period, clearly defective embryos stop developing.
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  • 4Embryo transfer

    Embryo
    transfer

    After a successful cultivation progress in the lab, we will transfer the most suitable embryo into the uterus of the mother who will then enter into the childbearing phase of her pregnancy.
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  • 0.Day

    Preparatory phase

  • Your journey toward conception of a healthy baby using the help of Assisted Reproduction begins at our clinic with a consultation with our doctor. During the appointment, reproductive abilities of a couple are analysed in detail. Depending on this analysis, specific methods are recommended to you and a treatment plan is put together. A typical treatment course is introduced further.

  • Eggs

  • During the analysis of the reproductive ability of a woman, we discover how efficient her ovaries are, and evaluate the quality of her oocytes. Eggs are retrieved via puncture and gently applied suction from ovaries under short-term general anaesthesia. Donor eggs are recommended if the retrieval attempt from the mother yields no solution.

  • In such case, you will choose a suitable donor from our database and the treatment can continue without any delay. More information about this procedure is available in the “Egg Donation” section.

  • Sperm cells

  • According to sperm analysis, a suitable method of egg fertilization is determined. In the event of strong sperm analysis, it is possible to store the sperm through a process known as cryopreservation which allows the sperm to be used at a later date.
    If no sperm cells in the ejaculate are found capable of fertilization, surgical sperm retrieval from testicles using MESA or TESE guided by a urologists under general anaesthesia is recommended. If this method does not lead to retrieval of quality sperm cells, it is possible to use donor sperm if the couple wishes.

  • Egg fertilization and embryo development

  • The fertilization of an egg can either take place in a woman’s body (IUI) or outside of a woman’s body – a true in vitro fertilization solution (IVF, ICSI).

  • When speaking about IUI – intrauterine insemination, we mean a method when the prepared sperm cells are transferred directly into the woman’s uterus but the oocyte fertilization and everything else is dependent solely on nature. Of course, it is necessary to verify up front that a woman has passable fallopian tubes and sperm has a good motility, otherwise sperm would not reach an oocyte whatsoever. Due to the current trend of significant diminishment of sperm quality in the general male population, this is not one of the most sccessful methods of treatment.

  • The most fundamental method of Assisted Reproduction is IVF. During IVF, sperm in a special solution is added to the retrieved eggs in a special media, but the sperm has to naturally penetrate the individual eggs without any assistance. It is a matter of coincidence which sperm penetrates which oocytes.

  • An injection of sperm directly into the oocyte, ICSI method, limits this coincidence and increases the probability of conception. It is carried out under a microscope using micromanipulator.

  • The most recent studies indicate that it is of increasing importance to identify which sperm is truly healthy. Thus, we recommend PICSI (physiological ICSI), an additional and even more precise method for sperm selection. For oocyte fertilization, we use the sperm cells that are most attracted to a drop of the chemical substance that is also contained by an oocyte. This substance acts as if it were a magnet.

  • If the sperm quality is at critical levels and sperm of abnormal shapes dominate, an IMSI method is available for the right sperm selection. The selection is carried out via a special microscope that enlarges sperm cell up to 6000 times. This allows the doctors to choose sperm cells with a normal morphology, normal head appearance: both indicators of healthy sperm. These sperm are then injected into the individual eggs.

  • 1.-5.Day

    Embryo cultivation

  • An embryo comes into existence by oocyte fertilization. Unfortunately, it is impossible to ensure that the connection between a sperm cell and an egg develops only into perfect embryos. In fact, how maternal and paternal genetic information mixes inside of an oocyte cannot be influenced by science. It is a matter of coincidence.

  • Prolonged cultivation of embryos is the most basic tool. This allows the Doctors to distinguish between healthy and imperfect embryos. Completely defective embryos will stop developing during the first five days in the lab. The embryos that continue to develop up until day 5 can be considered healthy. One, (or two, under exceptional circumstances) embryo will be transferred into the uterus and the rest of the available quality embryos can be cryopreserved, upon the request of the patients.

  • We utilize a special cultivation incubator, an EmbryoScope, for more elaborate analysis of embryo development, in which a micro camera films every embryo during the whole time of development, so we have more available pieces of information about embryos to assess their development and determine whether they are “healthy” before the embryo transfer.

  • When a risk of congenital genetic diseases is increased, we can assess chromosomal genetic characteristics of an embryo via PGD (pre-implantation genetic diagnosis) and eliminate the transfer of a defective embryo.

  • 5.Day

    Transfer of an embryo into a uterus

  • After successful cultivation, the suitable embryo is carried (transferred) into a uterus. The embryo transfer represents the peak of the whole treatment. To perform the transfer successfully, basic conditions must be met – the cervical canal patency has to be ensured, the appropriate transfer catheter has to be chosen, and the suitable transfer technique has to be used. We choose the catheter for the transfer based on the individual shape and size of the uterus specific to every individual woman.

  • Non-transferred developing embryos can be cryopreserved via a CryoTop method, preserved in our Cryobank. This provides the opportunity to conceive another child at a later date by thawing a fertilized embryo (FET).

  • 6.-7.Day

    Embryo implantation

  • On day six and seven of embryonic development, thus one or two days after the embryo transfer, an embryo implants into the endometrial lining. Implantation represents a “dialogue” between the embryo and the lining. The implantation is influenced by different factors and mediators, which are not perceptible via any visual technique. The endometrial height visible on the ultrasound is an indicator to be considered.

  • The chance for successful embryo implantation can be increased by transferring a supportive medium (ISMT) into a uterus before the actual embryo transfer has taken place.

  • In our yearly study, the conception rate in the group of women after application of ISMT rises by 23% compared to patients who chose not to proceed with the ISMT.

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Any further questions? Our coordinator will answer all your questions and arrange everything for your upcoming visit to our clinic.

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